Fujita Y, Inoue S, Horiguchi S, Kuki A
Sumiyoshigawa Hospital, Kobe, Japan.
Miner Electrolyte Metab. 1995;21(1-3):50-4.
We examined the effect of total parathyroidectomy (PTX) on renal anemia in 20 dialysis patients with secondary hyperparathyroidism. We obtained the following results. (1) Before PTX, 13 of these patients were not treated with erythropoietin (EPO) while the remaining 7 patients received EPO therapy. (2) In 8 out of 13 cases without recombinant human EPO treatment before PTX, a 10% increase in RBC was observed after PTX. (3) In 7 of the patients who were treated with EPO before PTX, anemia was improved after PTX despite discontinuation of EPO therapy in 2, a reduced dose of EPO in 3 and the same dose of EPO in 2. Our data is consistent with the notion that elevated blood levels of PTH in patients with chronic renal failure participate in the genesis of anemia of renal failure.
我们研究了20例继发性甲状旁腺功能亢进的透析患者行甲状旁腺全切除术（PTX）对肾性贫血的影响。我们得到了以下结果。（1）PTX前，其中13例患者未接受促红细胞生成素（EPO）治疗，其余7例患者接受EPO治疗。（2）在PTX前未接受重组人EPO治疗的13例患者中，有8例在PTX后观察到红细胞计数增加了10%。（3）在PTX前接受EPO治疗的7例患者中，PTX后贫血得到改善，其中2例停用EPO治疗，3例EPO剂量减少，2例EPO剂量不变。我们的数据与慢性肾衰竭患者血中甲状旁腺激素水平升高参与肾衰竭贫血发生的观点一致。
