Altavilla G, Blandamura S, Gardiman M, Salmaso R, Piazza M
Istituto di Anatomia Patologica, Università di Padova.
Pathologica. 1995 Feb;87(1):82-6.
A 60-year-old man with a large pericardial effusion was found to have a large intrapericardial mass located anteriorly to the right ventricle and firmly attached to the ascending aorta and pulmonary trunk. Histologically the mass, which was completely excised together with its large base of implant, was found to be a Solitary Fibrous Tumor. After a 46-months follow-up the patient is free from symptoms and signs of recurrence. Solitary Fibrous Tumor is considered a benign tumor and its excision curative, however aggressive variants and metastasis have been reported. Patternless architecture, fibrous collagenous stroma, exclusive vimentin positivity and the lack of ultrastructural mesothelial markers are important tools for the diagnosis. Because of the extreme rarity of intrapericardial location and lack of information on long-term behaviour of this tumor, close non-invasive follow-up is necessary.
一名60岁男性,伴有大量心包积液,发现右心室前方有心包内巨大肿块,且该肿块与升主动脉和肺动脉主干紧密相连。组织学检查显示,连同其大的植入基底一并完整切除的肿块为孤立性纤维瘤。经过46个月的随访,患者无复发症状和体征。孤立性纤维瘤被认为是一种良性肿瘤,切除可治愈,但也有侵袭性变体和转移的报道。无特定结构、纤维胶原性间质、仅波形蛋白阳性以及缺乏超微结构间皮标志物是诊断的重要依据。由于心包内定位极其罕见,且缺乏关于该肿瘤长期行为的信息,因此需要密切的非侵入性随访。