Deltenre M, Jonas C, Buset M, Denis P, De Koster E
Clinic of Gastro Enterology, University Hospital Brugmann ULB VUB, Brussels.
Acta Gastroenterol Belg. 1995 Mar-Apr;58(2):193-200.
Gastric carcinoma is the world's overall second most common cancer. Besides obvious environmental factors, recent epidemiological studies and a better knowledge of Helicobacter Pylori biological properties revealed that the microorganism is involved in the first steps of gastric carcinogenesis as proposed by the Correa model (from normal gastric tissue through superficial gastritis, multifocal atrophic gastritis, intestinal metaplasia and dysplasia to carcinoma). Significant correlation between the prevalence of H. pylori infection and incidence of gastric carcinoma (mainly the intestinal type) in various geographical areas has been reported. The high prevalence of HP in pre-neoplastic states and in cases of early gastric cancer indicates the infection would precede the development of gastric cancer. HP-related chronic inflammation of gastric mucosa with increased mucosal cell proliferation, deficit in local ascorbic acid concentration, topical ammonia toxicity are putative mechanisms that overexpose a weakened gastric mucosa to environmental carcinogens.
胃癌是全球总体上第二常见的癌症。除了明显的环境因素外，最近的流行病学研究以及对幽门螺杆菌生物学特性的更深入了解表明，正如科雷亚模型所提出的那样（从正常胃组织经过浅表性胃炎、多灶性萎缩性胃炎、肠化生和发育异常到癌症），这种微生物参与了胃癌发生的最初阶段。据报道，在不同地理区域，幽门螺杆菌感染率与胃癌（主要是肠型）发病率之间存在显著相关性。幽门螺杆菌在癌前状态和早期胃癌病例中的高感染率表明，感染先于胃癌的发生。幽门螺杆菌相关的胃黏膜慢性炎症，伴有黏膜细胞增殖增加、局部抗坏血酸浓度不足、局部氨毒性，这些都是可能的机制，使脆弱的胃黏膜过度暴露于环境致癌物中。
