Synthesis and DNA binding properties of C3-, C12-, and C24-substituted amino-steroids derived from bile acids.
作者信息
Hsieh H P, Muller J G, Burrows C J
机构信息
Department of Chemistry, State University of New York, Stony Brook 11794-3400, USA.
出版信息
Bioorg Med Chem. 1995 Jun;3(6):823-38. doi: 10.1016/0968-0896(95)00060-t.
PMID:7582959
Abstract
Seven new amino- and guanidino-substituted steroids have been synthesized from bile acid precursors, either deoxycholic acid or lithocholic acid. Their DNA binding properties have been examined using an ethidium displacement assay, through studies of hyperchromicity and thermal denaturation, and by circular dichroism. Comparison is made to simple aliphatic polyamines such as putrescine, 1,12-diaminododecane, spermidine, and spermine.
摘要
Zotero 插件