前列腺素E2和前列腺素F2α对Oddi括约肌节律性收缩的影响。

The effects of PGE2 and PGF2 alpha on rhythmic contractions of sphincter of Oddi.

Göçer F, Yariş E, Tuncer M

Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Gen Pharmacol. 1995 Oct;26(6):1397-401. doi: 10.1016/0306-3623(94)00308-a.

Abstract

Spontaneous rhythmic activity observed in some of the guinea-pig sphincter of Oddi preparations was completely abolished by PGE2 (10(-8) M) but not altered by PGF2 alpha (10(-6) M). 2. Indomethacin (10(-5) M), a cyclooxygenase inhibitor, elicited long-lasting rhythmic contractions in 50% of the preparations tested, which did not show any spontaneous activity. PGE2 (10(-8) M) completely inhibited, however PGF2 alpha (10(-8)-10(-6) M) did not change the rhythmic contractions induced by indomethacin. 3. Both initial phasic contraction and the frequency and amplitude of peristaltic waves induced by ACh (10(-3) M) were increased by indomethacin (10(-5) M), decreased by PGE2 (10(-7) M) and not altered by PGF2 alpha (10(-7) M).

摘要

在部分豚鼠奥迪括约肌标本中观察到的自发性节律活动被前列腺素E2（10^(-8) M）完全消除，但未被前列腺素F2α（10^(-6) M）改变。2. 环氧化酶抑制剂吲哚美辛（10^(-5) M）在50%的受试标本中引发了持久的节律性收缩，这些标本未表现出任何自发性活动。然而，前列腺素E2（10^(-8) M）完全抑制了这种收缩，而前列腺素F2α（10^(-8) - 10^(-6) M）并未改变吲哚美辛诱导的节律性收缩。3. 乙酰胆碱（10^(-3) M）诱导的初始相性收缩以及蠕动波的频率和幅度，均被吲哚美辛（10^(-5) M）增加，被前列腺素E2（10^(-7) M）降低，且未被前列腺素F2α（10^(-7) M）改变。