Miliotis M D, Tall B D, Gray R T
Division of Virulence Assessment, U.S. Food and Drug Administration, Washington, D.C. 20204, USA.
Infect Immun. 1995 Dec;63(12):4959-63. doi: 10.1128/iai.63.12.4959-4963.1995.
The adherence to and invasion of cultured epithelial cells by Vibrio hollisae were examined by quantitative studies and by light, fluorescent, and electron microscopy. Condensed actin was observed around clustered adherent and intracellular bacteria. Bacteria multiplied intracellularly. Inhibitor studies indicated that internalization occurred by an integrated pleiotropic process involving eukaryotic and prokaryotic protein syntheses, microfilaments, microtubules, and receptor-mediated endocytosis.
通过定量研究以及光学显微镜、荧光显微镜和电子显微镜,对霍利斯弧菌对培养上皮细胞的黏附和侵袭进行了检测。在聚集的黏附细菌和细胞内细菌周围观察到浓缩的肌动蛋白。细菌在细胞内繁殖。抑制剂研究表明,内化通过一个综合的多效性过程发生,该过程涉及真核和原核蛋白质合成、微丝、微管以及受体介导的内吞作用。