Ikeda H, Shino A, Nagaoka A
Eur J Pharmacol. 1979 Jan 1;53(2):173-9. doi: 10.1016/0014-2999(79)90163-8.
Neonates of male stroke-prone spontaneously hypertensive rats (SHRSP) were treated with 6-hydroxydopamine (6-OHDA) on two different schedules. Peripheral sympathectomy, which was evaluated by the pressor response to exogenous noradrenaline (NA) or by the decrease in NA content of the spleen, was more evident in the NB-8 group (treated on 8th and 15th day after birth) than in the NB-1 group (treated at 6, 24 and 72 h after birth). The reduction of the NA content in the cerebral cortex was more prominent in the NB-1 group than in the NB-8 group. The blood pressure from 7 to 23 weeks of age was lower in the treated groups: NB-8 less than NB-1 less than control. Therefore, the reduction of blood pressure in the treated groups could be related to the severity of peripheral sympathectomy. The incidence of sroke was also lower in the treated groups: 38, 11 and 0% in the control NB-1 and NB-8 groups, respectively. Loading with 1% NaCl solution from 11 weeks of age enhanced the rise in blood pressure and increased the incidence of stroke in each group of rats: 100, 20 and 40% in the control. NB-1 and NB-8 groups, respectively. However, the onset of stroke after exhibiting a severe hypertension (greater than 200 mmHg) was delayed in the treated groups. It seems that the activated tone in the peripheral sympathetic nerve is likely to participate in the development of spontaneous hypertension. In addition to the high blood pressure level, the activated tone of sympathetic nerve innervating the cerebral vasculature may be partly involved in the development of stroke in the new strain of the SHR rats, SHRSP.
对雄性易中风自发性高血压大鼠（SHRSP）的新生幼鼠采用两种不同方案用6-羟基多巴胺（6-OHDA）进行处理。通过对外源性去甲肾上腺素（NA）的升压反应或脾脏NA含量的降低来评估外周交感神经切除术，结果显示，NB-8组（出生后第8天和第15天进行处理）的外周交感神经切除术比NB-1组（出生后6、24和72小时进行处理）更明显。NB-1组大脑皮质中NA含量的降低比NB-8组更显著。治疗组7至23周龄时的血压较低：NB-8组低于NB-1组低于对照组。因此，治疗组血压的降低可能与外周交感神经切除术的严重程度有关。治疗组的中风发生率也较低：对照组、NB-1组和NB-8组的中风发生率分别为38%、11%和0%。11周龄开始用1%氯化钠溶液灌胃会使每组大鼠的血压升高并增加中风发生率：对照组、NB-1组和NB-8组的中风发生率分别为100%、20%和40%。然而，治疗组在出现严重高血压（大于200 mmHg）后中风的发作延迟。外周交感神经的激活状态似乎可能参与自发性高血压的发展。除了高血压水平外，支配脑血管的交感神经的激活状态可能部分参与了SHR大鼠新菌株SHRSP中风的发展。
