Tholstrup T, Marckmann P, Vessby B, Sandström B
Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
J Lipid Res. 1995 Jul;36(7):1447-52.
Plasma lipoprotein[a] (Lp[a]) is associated with atherogenesis and thrombogenesis. We examined how plasma Lp[a] in healthy young men was affected by fats high in stearic (C18), palmitic (C16), and lauric+myristic (C12+ C14) acid (experiment I, 15 subjects), and by fats high in myristic (C14) and palmitic (C16) acid (experiment II, 12 subjects). Strictly controlled isocaloric diets with 36% of energy from test fats were served in random order for 3 weeks separated by wash-out period(s). Diets high in C18 gave significantly higher levels of Lp[a] (51(12-560) mg/L) than diets high in C16 (38(12-533 mg/L) (P = 0.020) and C12 + C14 (34(12-534) mg/L) (P = 0.002). These differences were observed in several of the subjects in experiment I. In experiment II we saw no difference in plasma Lp[a] after diets high in C16 and C14. Our observations suggest that a fat high in stearic acid might affect Lp[a] in a different way than fats high in palmitic and myristic+lauric acid. Lp[a] concentrations were not associate with changes in tissue-plasminogen activator (t-PA) activity, factor VII coagualant activity, or plasma LDL cholesterol.
血浆脂蛋白[a]（Lp[a]）与动脉粥样硬化形成和血栓形成有关。我们研究了健康年轻男性的血浆Lp[a]如何受到硬脂酸（C18）、棕榈酸（C16）以及月桂酸+肉豆蔻酸（C12 + C14）含量高的脂肪的影响（实验I，15名受试者），以及肉豆蔻酸（C14）和棕榈酸（C16）含量高的脂肪的影响（实验II，12名受试者）。严格控制等热量饮食，其中36%的能量来自测试脂肪，以随机顺序提供，为期3周，中间有洗脱期。富含C18的饮食使Lp[a]水平（51（12 - 560）mg/L）显著高于富含C16的饮食（38（12 - 533）mg/L）（P = 0.020）和富含C12 + C14的饮食（34（12 - 534）mg/L）（P = 0.002）。在实验I的几名受试者中观察到了这些差异。在实验II中，我们发现富含C16和C14的饮食后血浆Lp[a]没有差异。我们的观察结果表明，富含硬脂酸的脂肪可能以与富含棕榈酸、肉豆蔻酸+月桂酸的脂肪不同的方式影响Lp[a]。Lp[a]浓度与组织纤溶酶原激活物（t-PA）活性、因子VII凝血活性或血浆低密度脂蛋白胆固醇的变化无关。
