小鼠恒速给药后丙戊酸的时辰药代动力学及进食时间表的影响。
Chronopharmacokinetics of valproic acid following constant-rate administration in mice and influence of feeding schedule.
作者信息
Song J G, Ohdo S, Ogawa N
机构信息
Department of Pharmacology, Ehime University School of Medicine, Japan.
出版信息
Zhongguo Yao Li Xue Bao. 1995 Mar;16(2):113-7.
AIM
To study the circadian rhythm in pharmacokinetics of valproic acid (VA) and influence of feeding schedule on the rhythm.
METHODS
Sodium valproate was administered by osmotic minipump technique (1.062 mg.h-1) and i.v. (50 mg.kg-1) to ICR mice fed under ad lib or time-restricted schedules to determine the time-dependent changes of VA kinetics.
RESULTS
Plasma VA concentration and clearance at steady-state showed circadian rhythms (P < 0.01). Time-restricted feeding influenced the rhythm of VA kinetics, acrophases of rhythms shifted approximately 12 h.
CONCLUSION
Timing of dosing is important for VA kinetics and feeding schedule is one of synchronizers in VA kinetics.
目的
研究丙戊酸（VA）药代动力学的昼夜节律以及进食时间安排对该节律的影响。
方法
通过渗透微型泵技术（1.062毫克·小时⁻¹）和静脉注射（50毫克·千克⁻¹）给予丙戊酸钠，对自由进食或限时进食的ICR小鼠进行给药，以确定VA动力学的时间依赖性变化。
结果
稳态时血浆VA浓度和清除率呈现昼夜节律（P < 0.01）。限时进食影响了VA动力学的节律；节律的峰相位大约偏移了12小时。
结论
给药时间对于VA动力学很重要，进食时间安排是VA动力学中的同步因素之一。
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