帽结合复合体与细胞生长调控。
Cap binding complexes and cellular growth control.
作者信息
Mader S, Sonenberg N
机构信息
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
出版信息
Biochimie. 1995;77(1-2):40-4. doi: 10.1016/0300-9084(96)88102-8.
PMID:7599274
Abstract
The cap-binding complex eIF-4F plays a major role in the control of translation initiation, and overexpression of its limiting subunit, eIF-4E, leads to the deregulation of cellular growth. The recent cloning of eIF-4E binding proteins (4E-BPs) has uncovered a previously unsuspected pathway for the regulation of eIF-4E activity, through sequestration of eIF-4E as a complex with 4E-BPs.
摘要
帽结合复合物eIF-4F在翻译起始的控制中起主要作用，其限制性亚基eIF-4E的过表达会导致细胞生长失调。最近对eIF-4E结合蛋白（4E-BPs）的克隆揭示了一条以前未被怀疑的调节eIF-4E活性的途径，即通过将eIF-4E与4E-BPs形成复合物而使其隔离。
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