Gustaw P, Pawlik W W, Jacobson E D, Sendur R, Konturek S J
Institute of Physiology, Jagiellonian University School of Medicine, Cracow, Poland.
J Physiol Pharmacol. 1995 Mar;46(1):63-70.
The effects of periarterial placement of capsaicin upon intestinal blood flow, oxygen consumption and distribution of blood flow to the vascular compartments of the gut wall were measured in anesthetized dogs. Total blood flow to the segment of distal ileum was measured with an ultrasonic blood flowmeter and arteriovenous oxygen difference (AVO2) across the intestinal segment was determined spectrophotometrically. Intestinal oxygen uptake was calculated as the product of AVO2 and intestinal blood flow. Intestinal mucosal blood flow was also measured by laser-Doppler flowmeter. Changes in blood flow distribution were estimated from the distribution of radiolabeled microspheres. Capsaicin applied periarterially induced early increase in intestinal blood flow, oxygen uptake and increase in mucosal blood flow which was higher then increase in total blood flow. The acute capsaicin-induced vascular dilation was followed by steady state response characterized by significant decrease in intestinal blood flow, oxygen uptake and redistribution of blood flow away from mucosal-submucosal the intestinal compartment. The results of these studies indicate that sensory C-fibers at rest, and when activated play a role in the control of intestinal blood flow, its distribution among vascular compartments of the intestinal wall and intestinal tissue oxygenation.
在麻醉犬身上测量了辣椒素动脉周围给药对肠血流量、氧消耗以及肠壁血管腔血流分布的影响。用超声血流仪测量回肠远端节段的总血流量，并用分光光度法测定肠段的动静脉氧差（AVO2）。肠氧摄取量通过AVO2与肠血流量的乘积计算得出。肠黏膜血流量也用激光多普勒血流仪进行测量。根据放射性微球的分布估计血流分布的变化。动脉周围应用辣椒素可使肠血流量、氧摄取量早期增加，黏膜血流量增加，且黏膜血流量的增加高于总血流量的增加。辣椒素急性诱导的血管扩张之后是稳态反应，其特征是肠血流量、氧摄取量显著降低，血流从肠黏膜-黏膜下层重新分布。这些研究结果表明，静息时以及激活时的感觉C纤维在肠血流量控制、其在肠壁血管腔之间的分布以及肠组织氧合中发挥作用。
