Abuye C, Hailemariam B, Tibeb H N, Urga K, Gebru H
Ethiopian Nutrition Institute, Addis Abeba.
Ethiop Med J. 1995 Apr;33(2):115-23.
The effect of oral iodine supplementation on total goitre rate (%TGR) and urinary iodine excretion among school children 4 to 16 years of age was studied. In the first group (n = 57) 200mg oral iodized oil reduced %TGR from 31.6% to 17.5% and 33.3% to 24.6% in males and females respectively, while in the second group (n = 53), 400mg iodine reduced the %TGR from 34.0% to 20.8% in males and 35.9% to 24.5% in females after 13 months of intervention. This gave a relative indication that the 200mg is as effective as the 400mg in goitre reduction. In subsequent tests, the maximum urinary iodine excretion was obtained from the groups which received two doses of iodized oil 24 hours after the intervention. A significant (p = 0.003) greater increase in urinary iodine excretion was noted at 24 hours among both male and female children administered 400mg than among those who received 200mg. Measurements after 24 hours showed no significant difference between urinary iodine excretion of the two dose groups. These results suggest that: (i) 200mg is likely equally effective as 400mg for iodine deficiency disorders control and prevention among children and (ii) iodine could be administered annually rather than biannually.
研究了口服碘补充剂对4至16岁学龄儿童的甲状腺肿总患病率（%TGR）和尿碘排泄的影响。在第一组（n = 57）中，200mg口服碘油使男性和女性的%TGR分别从31.6%降至17.5%和从33.3%降至24.6%，而在第二组（n = 53）中，干预13个月后，400mg碘使男性的%TGR从34.0%降至20.8%，女性从35.9%降至24.5%。这相对表明200mg在减少甲状腺肿方面与400mg一样有效。在后续测试中，干预后24小时从接受两剂碘油的组中获得了最大尿碘排泄量。在给予400mg的男性和女性儿童中，24小时时尿碘排泄量的增加显著（p = 0.003）大于接受200mg的儿童。24小时后的测量显示两个剂量组的尿碘排泄量之间没有显著差异。这些结果表明：（i）200mg在控制和预防儿童碘缺乏症方面可能与400mg同样有效；（ii）碘可以每年给药一次而不是每半年给药一次。
