使用三氯碘硅烷作为Boc脱保护剂固相合成催产素。
Solid-phase synthesis of oxytocin using iodotrichlorosilane as Boc deprotecting agent.
作者信息
Sivanandaiah K M, Sureshbabu V V, Shankaramma S C
机构信息
Department of Studies in Chemistry, Central College, Bangalore University, Karnataka, India.
出版信息
Int J Pept Protein Res. 1995 Apr;45(4):377-9. doi: 10.1111/j.1399-3011.1995.tb01051.x.
Abstract
Deprotection of the tert-butoxycarbonyl group during solid-phase synthesis of peptides can be conveniently and efficiently carried out using a neutral reagent, silicon tetrachloride/sodium iodide (iodotrichlorosilane). This simple and rapid method has been advantageously employed during the solid-phase synthesis of the pituitary hormone, oxytocin.
摘要
在肽的固相合成过程中，叔丁氧羰基的脱保护可以使用中性试剂四氯化硅/碘化钠（碘三氯硅烷）方便且高效地进行。这种简单快速的方法已被成功应用于垂体激素催产素的固相合成中。
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