嗜酮脱硫杆菌对丁酸盐的分解代谢途径。
Pathway of butyrate catabolism by Desulfobacterium cetonicum.
作者信息
Janssen P H, Schink B
机构信息
Fakultät für Biologie, Universität Konstanz, Germany.
出版信息
J Bacteriol. 1995 Jul;177(13):3870-2. doi: 10.1128/jb.177.13.3870-3872.1995.
Abstract
Desulfobacterium cetonicum 480 oxidized butyrate to 1 mol of acetate and 2 mol of CO2; this reaction was coupled to reduction of sulfate to sulfide. Butyrate was activated by coenzyme A (CoA) transfer from acetyl-CoA, and butyryl-CoA was oxidized to acetyl-CoA by a classical beta-oxidation pathway. Acetyl-CoA was oxidized through the acetyl-CoA/carbon monoxide dehydrogenase pathway. There was a rapid exchange of 14CO2 into the intermediate CoA esters and into acetate and butyrate, showing that all of the steps involved in the oxidation of butyrate to acetyl-CoA are reversible.
摘要
嗜酮脱硫杆菌480可将丁酸盐氧化为1摩尔乙酸盐和2摩尔二氧化碳；该反应与硫酸盐还原为硫化物相偶联。丁酸盐通过辅酶A（CoA）从乙酰辅酶A的转移而被激活，丁酰辅酶A通过经典的β-氧化途径被氧化为乙酰辅酶A。乙酰辅酶A通过乙酰辅酶A/一氧化碳脱氢酶途径被氧化。14CO2迅速交换到中间辅酶A酯以及乙酸盐和丁酸盐中，这表明丁酸盐氧化为乙酰辅酶A所涉及的所有步骤都是可逆的。
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