核酶：结构、特性及其作为潜在抗病毒剂的用途。
Ribozymes: structure, characteristics and use as potential antiviral agents.
作者信息
Bartolomé J, Madejón A, Carreño V
机构信息
Hepatology Unit, Fundación Jiménez Diaz, Madrid, Spain.
出版信息
J Hepatol. 1995;22(1 Suppl):57-64.
PMID:7602079
Abstract
Ribozymes are RNA molecules that can cut or ligate other RNA molecules catalytically. Several different ribozymes have been studied. In this paper, the hammerhead and the hepatitis delta virus (HDV) ribozymes are described, as well as their possible use as antiviral therapy.
摘要
核酶是能够催化切割或连接其他RNA分子的RNA分子。已经研究了几种不同的核酶。在本文中，描述了锤头状核酶和丁型肝炎病毒（HDV）核酶，以及它们作为抗病毒疗法的可能用途。
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Ribozymes: structure, characteristics and use as potential antiviral agents.核酶：结构、特性及其作为潜在抗病毒剂的用途。
J Hepatol. 1995;22(1 Suppl):57-64.
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Ribozymes as antiviral agents.作为抗病毒剂的核酶。
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Exploring the use of antisense, enzymatic RNA molecules (ribozymes) as therapeutic agents.探索将反义酶促RNA分子（核酶）用作治疗剂。
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Terbium-mediated footprinting probes a catalytic conformational switch in the antigenomic hepatitis delta virus ribozyme.铽介导的足迹法探测了反基因组丁型肝炎病毒核酶中的催化构象转换。
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Characterization of an HDV ribozyme which consists of three RNA oligomer strands.由三条RNA寡聚体链组成的丁型肝炎病毒核酶的特性分析。
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Structure-function relationship of hammerhead ribozymes as probed by 2'-modifications.通过2'-修饰探究锤头状核酶的结构-功能关系
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Ribozyme: a clinical tool.核酶：一种临床工具。
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Long-range impact of peripheral joining elements on structure and function of the hepatitis delta virus ribozyme.外周连接元件对丁型肝炎病毒核酶结构和功能的长期影响。
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[Investigation on activities of hammerhead ribozyme embedded in genomic RNA of hepatitis delta virus].[丁型肝炎病毒基因组RNA中嵌入的锤头状核酶活性研究]
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引用本文的文献
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Combinatorial screening and intracellular antiviral activity of hairpin ribozymes directed against hepatitis B virus.针对乙型肝炎病毒的发夹状核酶的组合筛选及细胞内抗病毒活性
J Virol. 1999 Jul;73(7):5381-7. doi: 10.1128/JVI.73.7.5381-5387.1999.
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