在同时接触铅的情况下进行二巯基丁二酸螯合：铅暴露小鼠的运动活动增加，但对照小鼠未出现此情况。

DMSA chelation during co-exposure to lead: increased locomotor activity in lead-exposed mice but not controls.

作者信息

Stewart P W, Burright R G, Donovick P J

机构信息

Department of Psychology, State University of New York at Binghamton 13902, USA.

出版信息

Physiol Behav. 1995 May;57(5):863-7. doi: 10.1016/0031-9384(94)00355-9.

DOI:10.1016/0031-9384(94)00355-9

PMID:7610136

Abstract

We investigated the effect of chelating agent meso-2,3 dimercaptosuccinic acid (DMSA) on indices of "hyperactive" behavior in lead-exposed and control Binghamton Heterogeneous Stock (Het) mice. As expected, 6 weeks of ingestion of 0.5% lead acetate in drinking water reduced immobility in a forced water swim relative to controls. DMSA did not attenuate this behavioral change. In fact, DMSA interacted with lead exposure to increase locomotor activity in the forced water swim. DMSA also apparently excacerbated lead's tendency to reduce immobility. While any generalizations to human populations should be cautioned, these results and others suggest the need for further research.

摘要

我们研究了螯合剂内消旋-2,3-二巯基琥珀酸（DMSA）对铅暴露的和对照的宾厄姆顿异质种群（Het）小鼠“多动”行为指标的影响。正如预期的那样，与对照组相比，饮用含0.5%醋酸铅的水6周会减少强迫水中游泳时的不动时间。DMSA并没有减弱这种行为变化。事实上，DMSA与铅暴露相互作用，增加了强迫水中游泳时的运动活性。DMSA显然也加剧了铅减少不动时间的趋势。虽然对人类群体进行任何概括都应谨慎，但这些结果及其他研究结果表明有必要进行进一步研究。