大剂量他莫昔芬治疗脑肿瘤：与抗癫痫药物的相互作用。

High-dose tamoxifen in treatment of brain tumors: interaction with antiepileptic drugs.

作者信息

Rabinowicz A L, Hinton D R, Dyck P, Couldwell W T

机构信息

USC Epilepsy Center, University of Southern California School of Medicine, Los Angeles, USA.

出版信息

Epilepsia. 1995 May;36(5):513-5. doi: 10.1111/j.1528-1157.1995.tb00494.x.

DOI:10.1111/j.1528-1157.1995.tb00494.x

PMID:7614929

Abstract

The incidence of seizures related to primary brain tumors is 20-80%. High-dose tamoxifen was recently reported as a novel treatment for patients with malignant gliomas who have failed standard therapies. Tamoxifen inhibits protein kinase C (PKC) in vitro and thus may regulate glioma cell growth by modulating intracellular signal transduction. We report a patient with a recurrent supratentorial pilocytic astrocytoma who had an untoward interaction between high-dose tamoxifen therapy and phenytoin (PHT), drugs that share a common enzyme for metabolism, therefore emphasizing the need to monitor concomitant antiepileptic drug (AED) levels when high-dose tamoxifen therapy is instituted.

摘要

与原发性脑肿瘤相关的癫痫发作发生率为20%-80%。最近有报道称，高剂量他莫昔芬可作为标准治疗失败的恶性胶质瘤患者的一种新疗法。他莫昔芬在体外可抑制蛋白激酶C（PKC），因此可能通过调节细胞内信号转导来调控胶质瘤细胞的生长。我们报告了1例幕上复发性毛细胞型星形细胞瘤患者，其在接受高剂量他莫昔芬治疗时与苯妥英（PHT）发生了不良相互作用，这两种药物具有共同的代谢酶，因此强调在开始高剂量他莫昔芬治疗时需要监测同时使用的抗癫痫药物（AED）水平。