Reinilä A, Akerblom H K, Koivisto V A
Diabetologia. 1979 Jan;16(1):59-64. doi: 10.1007/BF00423152.
The effect of insulin on the triglyceride deposits found in the pulmonary artery branches of streptozotocin-diabetic rats was investigated by treating the animals for two, five, nine or 14 days with insulin (3--8 units/day). Histochemical analysis showed that the triglyceride deposits in the pulmonary artery developed within three to four days after the induction of diabetes, but were not present in any animals five days from the initiation of insulin therapy. Plasma triglycerides, non-esterified fatty acids, phospholipid and total cholesterol concentrations were within the normal range within two days of the inception of insulin therapy and random plasma glucose levels were normal within five days. Analysis of lung lipids showed that after 14 days of insulin treatment the decreased content of phospholipids and the increased content of non-esterified fatty acids found in diabetic rats were also normalized. These findings suggest that insulin has an important role in the regulation of lipid metabolism in the pulmonary artery and lung tissue in the diabetic state.
通过用胰岛素（3 - 8单位/天）对链脲佐菌素诱导的糖尿病大鼠治疗2天、5天、9天或14天，研究了胰岛素对糖尿病大鼠肺动脉分支中甘油三酯沉积的影响。组织化学分析表明，糖尿病诱导后三到四天肺动脉中出现甘油三酯沉积，但在开始胰岛素治疗五天后的任何动物中均未出现。胰岛素治疗开始后两天内，血浆甘油三酯、非酯化脂肪酸、磷脂和总胆固醇浓度在正常范围内，随机血糖水平在五天内正常。肺脂质分析表明，胰岛素治疗14天后，糖尿病大鼠中发现的磷脂含量降低和非酯化脂肪酸含量增加也恢复正常。这些发现表明，胰岛素在糖尿病状态下对肺动脉和肺组织的脂质代谢调节中起重要作用。
