Dehpour A R, Farsam H, Azizabadi-Farahani M
Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Iran.
Neuropharmacology. 1995 Jan;34(1):115-21. doi: 10.1016/0028-3908(94)00121-8.
Due to the claim that lithium (Li+) reduces morphine self-administration in dependent rats, the effects of acute and chronic Li+ treatments on naloxone-precipitated withdrawal syndrome and physical dependence development to morphine in mice chronically treated with morphine, were evaluated. Morphine dependency was induced by the ingestion of morphine through drinking water in increasing doses for 10 days. Physical dependence to morphine was observed by precipitating an abstinence syndrome with naloxone (2 mg/kg, i.p.). In the acute experiments, Li+ (1 and 10 mg/kg, i.p.) was administered 1 hr prior to challenge with naloxone to morphine-dependent mice whereas for chronic studies, mice received morphine concomitant with Li+ (1200 mg/l) as drinking fluid for 10 days. Results obtained indicate that acute Li+ administration significantly reduced the withdrawal signs, and we were unable to induce some degree of morphine dependency in co-administration of Li+ to mice receiving chronic morphine treatment as compared to chronic morphine administration alone. The present study revealed that even in mice with very much lower serum Li+ levels than the commonly accepted therapeutic range there was a significant reduction in the withdrawal signs. It has been shown that Li+ and morphine have diverse effects on the transmembrane signal control systems. The interaction of Li+ and morphine might be through these systems.
由于有观点认为锂（Li+）可降低依赖大鼠的吗啡自我给药量，因此评估了急性和慢性Li+处理对长期接受吗啡治疗的小鼠纳洛酮诱发的戒断综合征以及对吗啡身体依赖性发展的影响。通过让小鼠饮用递增剂量的含吗啡饮水10天来诱导吗啡依赖性。通过用纳洛酮（2 mg/kg，腹腔注射）诱发戒断综合征来观察对吗啡的身体依赖性。在急性实验中，在对吗啡依赖小鼠用纳洛酮激发前1小时腹腔注射Li+（1和10 mg/kg），而在慢性研究中，小鼠饮用含Li+（1200 mg/l）的饮水并同时给予吗啡，持续10天。所得结果表明，急性给予Li+可显著减轻戒断症状，并且与单独长期给予吗啡相比，在长期接受吗啡治疗的小鼠中同时给予Li+时，我们无法诱导出一定程度的吗啡依赖性。本研究表明，即使在血清Li+水平远低于公认治疗范围的小鼠中，戒断症状也有显著减轻。已表明Li+和吗啡对跨膜信号控制系统有不同影响。Li+与吗啡的相互作用可能是通过这些系统。
