可溶性主要组织相容性复合体-肽复合物的二聚化足以激活T细胞杂交瘤并诱导无反应性。
Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness.
作者信息
Abastado J P, Lone Y C, Casrouge A, Boulot G, Kourilsky P
机构信息
Unité de Biologie Moléculaire du Gène, Institut National de la Santé et de la Recherche Medicale U277, Paris, France.
出版信息
J Exp Med. 1995 Aug 1;182(2):439-47. doi: 10.1084/jem.182.2.439.
Abstract
Major histocompatibility complex (MHC) class I molecules are cell-surface proteins that present peptides to CD8+ T cells. These peptides are mostly derived from endogenously synthesized protein. Recombinant, soluble MHC class I molecules were produced, purified, and loaded homogeneously with synthetic peptide. These MHC-peptide complexes were used to activate a T cell hybridoma. While monomers of MHC-peptide bound to the T cell, they showed no stimulatory activity. Dimers fully triggered the T cell hybridoma to secrete interleukin 2. This response was followed by a state in which the T cell was refractory to restimulation as a result of defective signal transduction through the T cell receptor.
摘要
主要组织相容性复合体（MHC）I类分子是将肽段呈递给CD8+ T细胞的细胞表面蛋白。这些肽段大多来源于内源性合成的蛋白质。制备、纯化了重组可溶性MHC I类分子，并使其均匀负载合成肽。这些MHC-肽复合物用于激活T细胞杂交瘤。虽然MHC-肽单体与T细胞结合，但它们没有刺激活性。二聚体完全触发T细胞杂交瘤分泌白细胞介素2。这种反应之后会进入一种状态，由于通过T细胞受体的信号转导存在缺陷，T细胞对再次刺激变得不应答。
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