伴有缺失和重复的倒位。
Inversions with deletions and duplications.
作者信息
Gordon A J, Halliday J A
机构信息
Section de Biologie, Institut Curie, Paris, France.
出版信息
Genetics. 1995 May;140(1):411-4. doi: 10.1093/genetics/140.1.411.
Abstract
Complex mutational events, including de novo inversion with deletion and duplication of sequence, have been observed but are difficult to model. We propose that nascent leading-strand misalignment upon the lagging-strand template during DNA replication can result in the inversion of sequence. The positioning of this misalignment and of the realignment of the leading strand back into the leading-strand template will determine if the inversion is accompanied by deletion and duplication of sequence. We suggest that such strand misalignment-realignment events may occur at the replication fork during concurrent DNA replication.
摘要
已观察到包括伴有序列缺失和重复的新生倒位在内的复杂突变事件，但难以对其进行建模。我们提出，在DNA复制过程中，滞后链模板上新生的前导链错配可导致序列倒位。这种错配以及前导链重新排列回到前导链模板的位置将决定倒位是否伴有序列的缺失和重复。我们认为，这种链错配-重新排列事件可能在DNA同时复制期间的复制叉处发生。
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