Reversal of multidrug resistance by novel cyclosporin A analogues and the cyclopeptolide SDZ 214-103 biosynthesized in vitro. - Suppr | 超能文献

Reversal of multidrug resistance by novel cyclosporin A analogues and the cyclopeptolide SDZ 214-103 biosynthesized in vitro.

作者信息

Schwabe K, Steinheider G, Lawen A, Traber R, Hildebrandt A

机构信息

Bundesinstitut für Arzneimittel und Medizinprodukte, Berlin, Federal Republic of Germany.

出版信息

J Cancer Res Clin Oncol. 1995;121(7):407-12. doi: 10.1007/BF01212947.

DOI:10.1007/BF01212947

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12200661/

Abstract

It was shown that cyclopeptolide SDZ 214-103 (10 microM) is more active in rhodamine-123 accumulation in actinomycin-D-resistant human lymphoma cells CCRF/ACTD400 than cyclosporin A (10 microM), but equipotent in the doxorubicin-resistant Friend erythroleukemia cell line F4-6/ADR. In F4-6/ADR cells, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay showed comparable cytotoxic effects of doxorubicin at various concentrations in the presence of SDZ 214-103 and cyclosporin A. For the other novel cyclosporin A analogues minor multidrug-resistance-modulating potency was demonstrated. At equipotent modulating doses of verapamil (10 microM) and cyclosporin A (10 microM) in the MTT assay regarding doxorubicin cytotoxicity, cyclosporin A was efficient in the rhodamine-123-uptake assay while verapamil was not active when identical incubation times were used.

摘要

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本文引用的文献

1

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

Cancer Res. 1993 Oct 1;53(19):4595-602.

2

Substrate specificities of cyclosporin synthetase and peptolide SDZ 214-103 synthetase. Comparison of the substrate specificities of the related multifunctional polypeptides.

J Biol Chem. 1993 Sep 25;268(27):20452-65.

3

In vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines A, C, D and metabolites M1, M17 and M21.

Immunopharmacol Immunotoxicol. 1993 Mar-Jun;15(2-3):163-77. doi: 10.3109/08923979309025992.

4

In vitro biosynthesis of peptolide SDZ 90-215 by a 1.2 MDa multienzyme polypeptide.

Biochem Mol Biol Int. 1993 Dec;31(5):797-805.

5

Derivatives of a novel cyclopeptolide. 2. Synthesis, activity against multidrug resistance in CHO and KB cells in vitro, and structure-activity relationships.

J Med Chem. 1994 Jun 24;37(13):1918-28. doi: 10.1021/jm00039a003.

6

Influence of dexniguldipine-HC1 on rhodamine-123 accumulation in a multidrug-resistant leukaemia cell line: comparison with other chemosensitisers.

Eur J Cancer. 1994;30A(8):1117-23. doi: 10.1016/0959-8049(94)90469-3.

7

Synthesis of mouse haemoglobin and globin mRNA in leukaemic cell cultures.

Nat New Biol. 1972 Oct 25;239(95):231-4. doi: 10.1038/newbio239231a0.

8

Reversal of resistance to rhodamine 123 in adriamycin-resistant Friend leukemia cells.

Cancer Res. 1985 Jun;45(6):2626-31.

9

Use of fluorescent dyes as molecular probes for the study of multidrug resistance.

Exp Cell Res. 1988 Jan;174(1):168-76. doi: 10.1016/0014-4827(88)90152-8.

10

Optimization of the tetrazolium-based colorimetric assay for the measurement of cell number and cytotoxicity.

Int J Immunopharmacol. 1988;10(7):785-93. doi: 10.1016/0192-0561(88)90001-x.

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