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[用于评估塔诺夫斯基古雷“西里西亚小镇”锌厂工人职业铅暴露的选定生物标志物]

[Selected biomarkers for evaluating occupational exposure to lead among workers from the "Miasteczko Slaskie" zincworks in Tarnowskie Gory].

作者信息

Kwapuliński J, Komosińska K, Wiechuła D, Kraśnicka A, Orczyk H

机构信息

Z Katedry i Zakładu Toksykologii, Slaskiej Akademii Medycznej, Oddział Sosnowcu.

出版信息

Med Pr. 1995;46(2):141-7.

PMID:7637632
Abstract

A dose-response relationship between exposure to lead and delta-aminolaevulinic acid concentration in urine (ALA-U), and between blood lead (Pb-B) and zinc protoporphyrin IX (ZPP-B) concentrations in blood were examined in 90 male workers exposed to lead. Concentrations of ZPP-B correlated closely with blood lead levels. Concentrations of ALA-U ranged from 1.6 to 19.4 mg/l. These data suggest that ALA-U is a useful indicator of early effects of exposure to lead on heam biosynthesis. Lead concentrations in air at different work posts were analysed. The results obtained were compared with the levels of standard values of lead concentrations in air and with blood lead levels at those work posts.

摘要

对90名接触铅的男性工人进行了研究,以检测铅暴露与尿中δ-氨基乙酰丙酸浓度(ALA-U)之间以及血铅(Pb-B)与血中锌原卟啉IX(ZPP-B)浓度之间的剂量反应关系。ZPP-B浓度与血铅水平密切相关。ALA-U浓度范围为1.6至19.4毫克/升。这些数据表明,ALA-U是铅暴露对血红素生物合成早期影响的有用指标。分析了不同工作岗位空气中的铅浓度。将所得结果与空气中铅浓度的标准值水平以及这些工作岗位的血铅水平进行了比较。

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