促黑素和促肾上腺皮质激素由七鳃鳗（现存最早进化的脊椎动物）的两个不同基因编码。
Melanotropin and corticotropin are encoded on two distinct genes in the lamprey, the earliest evolved extant vertebrate.
作者信息
Takahashi A, Amemiya Y, Sarashi M, Sower S A, Kawauchi H
机构信息
Laboratory of Molecular Endocrinology, School of Fisheries Sciences, Kitasato University, Iwate, Japan.
出版信息
Biochem Biophys Res Commun. 1995 Aug 15;213(2):490-8. doi: 10.1006/bbrc.1995.2158.
In the lamprey, which is a member of the oldest extant class of vertebrates, the agnathans, melanotropins (MSH) and corticotropin (ACTH) were found to be encoded on two distinct genes. In all other vertebrates, a single precursor gene, proopiomelanocortin (POMC), encodes MSH and ACTH, as well as beta-endorphin (END). Two different cDNAs were cloned from a lamprey pituitary lambda gt11 cDNA library using antisera against lamprey MSH-B and ACTH(1-16). One cDNA encoded MSH-B, MSH-A and beta-END, while the other cDNA encoded nasohypophysial factor (NHF), ACTH and a different beta-END, but not MSH-A and MSH-B. Northern blot analysis demonstrated that in the adult lamprey pituitary, genes for MSH and ACTH are expressed in the pars intermedia (PI) and pars distalis (PD), respectively.
七鳃鳗是现存最古老的脊椎动物纲——无颌类的成员，研究发现，七鳃鳗的促黑素（MSH）和促肾上腺皮质激素（ACTH）由两个不同的基因编码。在所有其他脊椎动物中，一个单一的前体基因——阿黑皮素原（POMC），编码MSH、ACTH以及β-内啡肽（END）。使用针对七鳃鳗MSH-B和ACTH(1-16)的抗血清，从七鳃鳗垂体λgt11 cDNA文库中克隆出了两种不同的cDNA。一种cDNA编码MSH-B、MSH-A和β-END，而另一种cDNA编码鼻垂体因子（NHF）、ACTH和一种不同的β-END，但不编码MSH-A和MSH-B。Northern印迹分析表明，在成年七鳃鳗垂体中，MSH和ACTH的基因分别在中间部（PI）和远侧部（PD）表达。
Zotero 插件