Oshika T
Division of Ophthalmology, Tokyo University Branch Hospital, Japan.
Drug Saf. 1995 Apr;12(4):256-63. doi: 10.2165/00002018-199512040-00005.
Neuropsychiatric agents may adversely affect the eye in various ways. The more frequently encountered effects include corneal oedema and pigmentary changes in the lens and cornea which are induced by phenothiazine derivatives; thioridazine-induced retinopathy; tricyclic antidepressant-induced accommodation interference and glaucoma; and lithium carbonate-induced exophthalmos and papilloedema. Several adverse effects, such as corneal oedema, retinopathy and glaucoma, are vision-threatening, and patients often fail to describe their symptoms properly. A more precise understanding of these conditions is essential for prompt diagnosis and appropriate treatment.
神经精神药物可能会以多种方式对眼睛产生不利影响。较常见的影响包括由吩噻嗪衍生物引起的角膜水肿以及晶状体和角膜的色素沉着变化；硫利达嗪引起的视网膜病变；三环类抗抑郁药引起的调节障碍和青光眼；以及碳酸锂引起的眼球突出和视乳头水肿。一些不良反应，如角膜水肿、视网膜病变和青光眼，会威胁视力，而患者往往不能正确描述他们的症状。对这些病症有更精确的了解对于及时诊断和恰当治疗至关重要。
