Confort-Gouny S, Mattéi J P, Vion-Dury J, Roux H, Bisset J P, Cozzone P J
Centre de Résonance Magnétique Biologique et Médicale, URA-CNRS 1186, Faculté de Médecine, Marseille, France.
Calcif Tissue Int. 1995 Jun;56(6):529-32. doi: 10.1007/BF00298583.
The values of in vivo T1 relaxation time (T1) of phosphorus atoms of wrist bone have been measured by phosphorus-31 magnetic resonance spectroscopy (MRS) in 65 menopausal women separated into three groups: (1) age-matched women without any paraclinical or clinical osteoporosis; (2) patients with paraclinical osteoporosis detected only by dual photonic absorptiometry; and (3) women with clinical osteoporosis with vertebral fractures. No significant differences were found in T1 values in the presence of paraclinical or clinical osteoporosis as compared to control values. No relationships were found among the T1, the value of the Z-score, the value of bone mineral content, the age of patients, the number of their children, and the age of menopause. Phosphorus-31 magnetic resonance spectroscopy of the wrist fails to separate osteoporotic from nonosteoporotic women and cannot be clinically used at this time to perform a noninvasive diagnosis of osteoporosis.
通过磷-31磁共振波谱法（MRS）测量了65名绝经后女性腕骨磷原子的体内T1弛豫时间（T1）值，这些女性被分为三组：（1）年龄匹配且无任何临床旁或临床骨质疏松症的女性；（2）仅通过双能光子吸收法检测出临床旁骨质疏松症的患者；（3）患有椎体骨折的临床骨质疏松症女性。与对照值相比，在存在临床旁或临床骨质疏松症的情况下，T1值未发现显著差异。在T1、Z评分值、骨矿物质含量值、患者年龄、子女数量和绝经年龄之间未发现相关性。腕骨的磷-31磁共振波谱法无法区分骨质疏松症女性和非骨质疏松症女性，目前不能在临床上用于对骨质疏松症进行无创诊断。
