pristane对大鼠细胞色素P - 4501A、鸟氨酸脱羧酶和腐胺的诱导作用

Pristane-induced effects on cytochrome P-4501A, ornithine decarboxylase and putrescine in rats.

作者信息

Harper C M, Soni M G, Mehendale H M, Cuchens M A

机构信息

Department of Microbiology, University of Mississippi Medical Center, Jackson 39216-4505, USA.

出版信息

Cancer Lett. 1995 Aug 16;95(1-2):11-21. doi: 10.1016/0304-3835(95)03855-q.

DOI:10.1016/0304-3835(95)03855-q

PMID:7656217

Abstract

The effects of pristane (2,6,10,14-tetramethylpentadecane) on cytochrome P-4501A (cP4501A) activity in microsomes, as well as on ornithine decarboxylase (ODC) activity and concomitant putrescine levels were examined in Copenhagen rats. In general, pristane treatment led to increased cP4501A levels when compared to basal levels, while co-treatment with 3-methylcholanthrene (3-MC) and pristane elicited augmented cP4501A responses when compared to responses induced by 3-MC alone. Increases in both ODC activity and putrescine levels were also observed in pristane treated rats. Collectively, these results indicate that pristane influences cP4501A activity and elicits promoter-like responses as reflected in elevated ODC activity and increased amount of putrescine.

摘要

在哥本哈根大鼠中，研究了降植烷（2,6,10,14-四甲基十五烷）对微粒体中细胞色素P-4501A（cP4501A）活性以及鸟氨酸脱羧酶（ODC）活性和随之产生的腐胺水平的影响。总体而言，与基础水平相比，降植烷处理导致cP4501A水平升高，而与单独用3-甲基胆蒽（3-MC）诱导的反应相比，3-甲基胆蒽（3-MC）与降植烷联合处理引发了增强的cP4501A反应。在降植烷处理的大鼠中还观察到ODC活性和腐胺水平均增加。总的来说，这些结果表明降植烷会影响cP4501A活性，并引发类似启动子的反应，表现为ODC活性升高和腐胺量增加。