• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Identification of an NF-kappa B binding site in the bovine leukemia virus promoter.牛白血病病毒启动子中NF-κB结合位点的鉴定。
J Virol. 1995 Oct;69(10):6005-9. doi: 10.1128/JVI.69.10.6005-6009.1995.
2
Suboptimal enhancer sequences are required for efficient bovine leukemia virus propagation in vivo: implications for viral latency.次优增强子序列是牛白血病病毒在体内高效传播所必需的：对病毒潜伏的影响。
J Virol. 2001 Aug;75(15):6977-88. doi: 10.1128/JVI.75.15.6977-6988.2001.
3
A cyclic AMP-responsive DNA-binding protein (CREB2) is a cellular transactivator of the bovine leukemia virus long terminal repeat.环磷酸腺苷应答性DNA结合蛋白（CREB2）是牛白血病病毒长末端重复序列的细胞反式激活因子。
J Virol. 1992 Feb;66(2):766-72. doi: 10.1128/JVI.66.2.766-772.1992.
4
A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation.HIV-1增强子激活需要NF-κB与Sp1之间的协同相互作用。
EMBO J. 1993 Sep;12(9):3551-8. doi: 10.1002/j.1460-2075.1993.tb06029.x.
5
I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding.IκB/MAD-3掩盖了NF-κB p65的核定位信号，并且需要反式激活结构域来抑制NF-κB p65与DNA的结合。
Mol Biol Cell. 1992 Dec;3(12):1339-52. doi: 10.1091/mbc.3.12.1339.
6
Two elements in the bovine leukemia virus long terminal repeat that regulate gene expression.牛白血病病毒长末端重复序列中调控基因表达的两个元件。
Science. 1986 Mar 21;231(4744):1437-40. doi: 10.1126/science.3006241.
7
Use of the bovine leukaemia virus LTR U3 promoter for expressing antisense antiviral RNAs and competitive inhibition of viral infection in cell culture.利用牛白血病病毒LTR U3启动子在细胞培养中表达反义抗病毒RNA并竞争性抑制病毒感染。
J Gen Virol. 1997 Aug;78 ( Pt 8):1941-8. doi: 10.1099/0022-1317-78-8-1941.
8
Transcriptional regulation of human polyomavirus JC: evidence for a functional interaction between RelA (p65) and the Y-box-binding protein, YB-1.人多瘤病毒 JC 的转录调控：RelA（p65）与 Y 盒结合蛋白 YB-1 之间功能相互作用的证据
J Virol. 1996 Sep;70(9):5944-53. doi: 10.1128/JVI.70.9.5944-5953.1996.
9
Interferon-alpha inhibits the murine cytomegalovirus immediate-early gene expression by down-regulating NF-kappa B activity.α干扰素通过下调核因子κB活性来抑制小鼠巨细胞病毒立即早期基因的表达。
Virology. 1995 Aug 1;211(1):251-60. doi: 10.1006/viro.1995.1398.
10
Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters.人巨细胞病毒通过反式激活核因子-κB p105/p50和p65启动子来上调核因子-κB活性。
J Virol. 1995 Sep;69(9):5391-400. doi: 10.1128/JVI.69.9.5391-5400.1995.

引用本文的文献

1
A complex network of transcription factors and epigenetic regulators involved in bovine leukemia virus transcriptional regulation.涉及牛白血病病毒转录调控的转录因子和表观遗传调节剂的复杂网络。
Retrovirology. 2023 Jun 2;20(1):11. doi: 10.1186/s12977-023-00623-w.
2
Effects of Naturally Occurring Mutations in Bovine Leukemia Virus 5'-LTR and Tax Gene on Viral Transcriptional Activity.牛白血病病毒5'-LTR和Tax基因自然发生的突变对病毒转录活性的影响。
Pathogens. 2020 Oct 13;9(10):836. doi: 10.3390/pathogens9100836.
3
Bovine leukemia virus long terminal repeat variability: identification of single nucleotide polymorphisms in regulatory sequences.牛白血病病毒长末端重复序列变异性：调节序列中单核苷酸多态性的鉴定。
Virol J. 2018 Oct 25;15(1):165. doi: 10.1186/s12985-018-1062-z.
4
Defibrinated bovine plasma inhibits retroviral transcription by blocking p52 activation of the NFkappaB element in the long terminal repeat.去纤维牛血浆通过阻断长末端重复序列中NFκB元件的p52激活来抑制逆转录病毒转录。
Can J Vet Res. 2007 Apr;71(2):119-28.
5
Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human.牛白血病病毒诱发白血病的机制：人类新型抗逆转录病毒疗法的前景
Retrovirology. 2007 Mar 16;4:18. doi: 10.1186/1742-4690-4-18.
6
Inhibition of histone deacetylases induces bovine leukemia virus expression in vitro and in vivo.组蛋白脱乙酰酶的抑制在体外和体内均可诱导牛白血病病毒的表达。
J Virol. 2002 May;76(10):5034-42. doi: 10.1128/jvi.76.10.5034-5042.2002.
7
Suboptimal enhancer sequences are required for efficient bovine leukemia virus propagation in vivo: implications for viral latency.次优增强子序列是牛白血病病毒在体内高效传播所必需的：对病毒潜伏的影响。
J Virol. 2001 Aug;75(15):6977-88. doi: 10.1128/JVI.75.15.6977-6988.2001.
8
The region between amino acids 245 and 265 of the bovine leukemia virus (BLV) tax protein restricts transactivation not only via the BLV enhancer but also via other retrovirus enhancers.牛白血病病毒（BLV）Tax蛋白的氨基酸245至265之间的区域不仅通过BLV增强子，还通过其他逆转录病毒增强子来限制反式激活。
J Virol. 2000 Dec;74(23):10939-49. doi: 10.1128/jvi.74.23.10939-10949.2000.
9
Prostaglandin E(2) increases bovine leukemia virus tax and pol mRNA levels via cyclooxygenase 2: regulation by interleukin-2, interleukin-10, and bovine leukemia virus.前列腺素E(2)通过环氧化酶2增加牛白血病病毒tax和pol mRNA水平：受白细胞介素-2、白细胞介素-10和牛白血病病毒调控。
J Virol. 2000 Jun;74(12):5740-5. doi: 10.1128/jvi.74.12.5740-5745.2000.
10
Sequences between the enhancer and promoter in the long terminal repeat affect murine leukemia virus pathogenicity and replication in the thymus.长末端重复序列中增强子与启动子之间的序列影响小鼠白血病病毒的致病性及在胸腺中的复制。
J Virol. 1999 Jun;73(6):4890-8. doi: 10.1128/JVI.73.6.4890-4898.1999.

本文引用的文献

1
The inducible transcription factor NF-kappa B: structure-function relationship of its protein subunits.诱导型转录因子核因子-κB：其蛋白质亚基的结构-功能关系
Biochem J. 1993 Mar 1;290 ( Pt 2)(Pt 2):297-308. doi: 10.1042/bj2900297.
2
Transactivation by the human T-cell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) ATF-2 response and cAMP element-binding protein (CREB).人类T细胞白血病病毒Tax蛋白的反式激活作用是通过增强激活转录因子2（ATF-2）、ATF-2反应元件和环磷酸腺苷反应元件结合蛋白（CREB）的结合来介导的。
J Biol Chem. 1993 Oct 5;268(28):21225-31.
3
Pleiotropic effect of the human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factors.人类T细胞白血病病毒Tax蛋白对真核转录因子DNA结合活性的多效性作用。
Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7303-7. doi: 10.1073/pnas.90.15.7303.
4
Nuclear factor kappa B, a mediator of lipopolysaccharide effects.核因子κB，脂多糖效应的介质。
Immunobiology. 1993 Apr;187(3-5):233-56. doi: 10.1016/S0171-2985(11)80342-6.
5
A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization.一种包含p65同型二聚体的新型核因子-κB复合物：对亚基二聚化水平转录调控的影响。
Mol Cell Biol. 1993 Dec;13(12):7826-35. doi: 10.1128/mcb.13.12.7826-7835.1993.
6
Tax protein of human T-lymphotropic virus type I triggers DNA damage.人类嗜T淋巴细胞病毒I型的Tax蛋白引发DNA损伤。
Leuk Lymphoma. 1994 Jan;12(3-4):281-6. doi: 10.3109/10428199409059600.
7
Characterization of NF(P), the nuclear factor that interacts with the regulatory P sequence (5'-CGAAAATTTCC-3') of the human interleukin-4 gene: relationship to NF-kappa B and NF-AT.与人白细胞介素-4基因调控性P序列（5'-CGAAAATTTCC-3'）相互作用的核因子NF(P)的特性：与核因子κB和活化T细胞核因子的关系
Biochem Biophys Res Commun. 1994 Mar 15;199(2):439-46. doi: 10.1006/bbrc.1994.1248.
8
Involvement of the cyclic AMP-responsive element binding protein in bovine leukemia virus expression in vivo.环磷酸腺苷反应元件结合蛋白参与牛白血病病毒的体内表达。
J Virol. 1994 Sep;68(9):5845-53. doi: 10.1128/JVI.68.9.5845-5853.1994.
9
Function and activation of NF-kappa B in the immune system.免疫系统中核因子-κB的功能与激活
Annu Rev Immunol. 1994;12:141-79. doi: 10.1146/annurev.iy.12.040194.001041.
10
Enhanced B-lymphocyte expression of IL-2R alpha associated with T lymphocytosis in BLV-infected persistently lymphocytotic cows.在感染牛白血病病毒（BLV）且持续淋巴细胞增多的奶牛中，白细胞介素-2受体α（IL-2Rα）的B淋巴细胞表达增强与T淋巴细胞增多相关。
Leukemia. 1994 Jun;8(6):1057-61.

牛白血病病毒启动子中NF-κB结合位点的鉴定。

Identification of an NF-kappa B binding site in the bovine leukemia virus promoter.

作者信息

Brooks P A, Nyborg J K, Cockerell G L

机构信息

Department of Pathology, Colorado State University, Fort Collins 80523, USA.

出版信息

J Virol. 1995 Oct;69(10):6005-9. doi: 10.1128/JVI.69.10.6005-6009.1995.

DOI:10.1128/JVI.69.10.6005-6009.1995
PMID:7666505
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189496/
Abstract

Although the mechanism by which bovine leukemia virus (BLV) induces neoplastic transformation of the host B cells is unknown, it is likely that critical interactions between cellular DNA-binding proteins and the virus are involved. We have used DNase I protection (footprinting) assays to construct a map of protein-DNA interactions on the 5' long terminal repeat of BLV. In addition to the three cyclic AMP response elements previously reported, we have also found an NF-kappa B binding site between -118 and -70 nucleotides upstream of the RNA start site. This site binds several members of the kappa B family of proteins, including p49, p50, and p65, in both footprint and electrophoretic mobility shift assays and functions as an enhancer element when inserted upstream of the chloramphenicol acetyltransferase gene. NF-kappa B may be a critical nuclear binding protein that regulates both viral replication and key cellular genes in BLV-infected B cells.

摘要

尽管牛白血病病毒（BLV）诱导宿主B细胞发生肿瘤转化的机制尚不清楚，但细胞DNA结合蛋白与该病毒之间的关键相互作用可能参与其中。我们利用DNA酶I保护（足迹法）分析构建了BLV 5'长末端重复序列上蛋白质-DNA相互作用图谱。除了先前报道的三个环磷酸腺苷反应元件外，我们还在RNA起始位点上游-118至-70核苷酸之间发现了一个核因子κB（NF-κB）结合位点。在足迹法和电泳迁移率变动分析中，该位点能结合κB家族的几种蛋白质成员，包括p49、p50和p65，并且当插入氯霉素乙酰转移酶基因上游时可作为增强子元件发挥作用。NF-κB可能是一种关键的核结合蛋白，它在BLV感染的B细胞中调节病毒复制和关键细胞基因。