[高等级颈动脉狭窄的对比增强彩色编码双功超声检查]

[Contrast-enhanced color-coded duplex ultrasound of high grade carotid stenoses].

作者信息

Fürst G, Sitzer M, Hofer M, Steinmetz H, Hackländer T, Mödder U

机构信息

Institut für Diagnostische Radiologie Heinrich-Heine-Universität, Düsseldorf.

出版信息

Ultraschall Med. 1995 Jun;16(3):140-4. doi: 10.1055/s-2007-1003928.

DOI:10.1055/s-2007-1003928

PMID:7667623

Abstract

PURPOSE AND METHODS

The usefulness of SH-U-508A (Laevovist) in the quantification of high-grade internal carotid stenosis (ICA) is assessed in this study. 32 patients with high-grade ICA stenosis (> = 70%) or occlusion are examined using colour Doppler-assisted duplex imaging (CDDI) before and after injection of SH-U-508A.

RESULTS

The SH-U-508A-induced increase in blood echogenicity started at 9.8 s (mean; SD: 2.2) after bolus injection and peaked at 21 dB (mean; SD: 1.9; n = 12) after 14.8 s (mean; SD: 2.9). In addition, SH-U-508A led to a significant increase in systolic peak velocity determined in the common carotid artery, by 26% (mean; SD: 9; p < 0.05). Significant differences between non-enhanced and enhanced CDDI were found for the visualisation of the entire length of the intrastenotic residual lumen (43% vs 83%; p < 0.01). Correlations between non-enhanced and enhanced CDDI were high (r > 0.9) for the determination of cross-sectional area reduction and plaque length.

CONCLUSION

SH-U-508A may be useful in quantifying high-grade ICA stenoses with insufficient delineation at non-enhanced CDDI.

摘要

目的与方法

本研究评估了SH-U-508A（Levovist）在定量检测重度颈内动脉狭窄（ICA）中的作用。对32例重度ICA狭窄（≥70%）或闭塞患者在注射SH-U-508A前后采用彩色多普勒辅助双功成像（CDDI）进行检查。

结果

推注SH-U-508A后，血液回声增强从9.8秒（均值；标准差：2.2）开始，在14.8秒（均值；标准差：2.9）后达到21分贝（均值；标准差：1.9；n = 12）的峰值。此外，SH-U-508A使颈总动脉测定的收缩期峰值速度显著增加26%（均值；标准差：9；p < 0.05）。在观察狭窄内残余管腔全长的可视化方面，未增强和增强后的CDDI存在显著差异（43%对83%；p < 0.01）。在测定横截面积减小和斑块长度方面，未增强和增强后的CDDI之间相关性很高（r > 0.9）。