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吡柔比星、异环磷酰胺和硫酸长春新碱联合治疗晚期滑膜肉瘤的疗效——1例报告

[Combination effect of pirarubicin, ifosfamide, and vincristine sulfate in the treatment of advanced synovial sarcoma--report of a case].

作者信息

Shinozaki T, Matsushita M, Kusawake H, Watanabe H, Arita S, Chigira M, Udagawa E

机构信息

Dept. of Orthopedic Surgery, Gunma University School of Medicine.

出版信息

Gan To Kagaku Ryoho. 1995 Sep;22(10):1389-91.

PMID:7668875
Abstract

Synovial sarcoma with pulmonary metastases appeared to be sensitive to multiagent chemotherapy of Pirarubicin, Ifosfamide, and Vincristine Sulfate. However, this chemotherapy regimen could not be continued because of severe hemorrhagic cystitis due to the toxicity of Ifosfamide. Even in the advanced stage, this multiagent chemotherapy would be useful for the treatment of synovial sarcoma, if hemorrhagic cystitis could be prevented.

摘要

伴有肺转移的滑膜肉瘤似乎对吡柔比星、异环磷酰胺和硫酸长春新碱的多药化疗敏感。然而,由于异环磷酰胺的毒性导致严重出血性膀胱炎,这种化疗方案无法继续。即使在晚期,如果能预防出血性膀胱炎,这种多药化疗对滑膜肉瘤的治疗也将是有用的。

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