使用外用二硝基氯苯治疗的HIV感染患者延迟型超敏反应皮肤试验结果得到改善。
Improved results of delayed-type hypersensitivity skin testing in HIV-infected patients treated with topical dinitrochlorobenzene.
作者信息
Stricker R B, Goldberg B, Mills L B, Epstein W L
机构信息
HemaCare Corporation, San Francisco, CA 94108, USA.
出版信息
J Am Acad Dermatol. 1995 Oct;33(4):608-11. doi: 10.1016/0190-9622(95)91279-7.
BACKGROUND
Infection with HIV results in progressive deterioration of cell-mediated immunity, with consequent impairment of delayed-type hypersensitivity (DTH) skin reactivity. Topical dinitrochlorobenzene (DNCB) is thought to increase cellular immune function in HIV infection.
OBJECTIVE
Our goal was to evaluate changes in DTH skin reactivity of HIV-infected patients who were given DNCB therapy.
METHODS
DTH skin testing and lymphocyte subset analysis were performed in five HIV-infected patients before the start of DNCB treatment and after 3 months of therapy. Topical DNCB application was carried out by the patients according to a standardized protocol.
RESULTS
DNCB therapy enhanced DTH skin test responses in four of five patients. Three patients who were anergic before the start of treatment reacted to skin test antigens while using DNCB. The skin test results did not correlate with lymphocyte subset changes.
CONCLUSION
DNCB treatment improves DTH skin test responses in HIV-infected patients, indicating a positive effect on cellular immune function.
背景
感染人类免疫缺陷病毒（HIV）会导致细胞介导免疫功能逐渐恶化，进而损害迟发型超敏反应（DTH）皮肤反应性。局部应用二硝基氯苯（DNCB）被认为可增强HIV感染患者的细胞免疫功能。
目的
我们的目标是评估接受DNCB治疗的HIV感染患者DTH皮肤反应性的变化。
方法
在5例HIV感染患者开始DNCB治疗前及治疗3个月后进行DTH皮肤试验和淋巴细胞亚群分析。患者按照标准化方案进行局部DNCB应用。
结果
DNCB治疗使5例患者中的4例DTH皮肤试验反应增强。3例治疗开始前无反应的患者在使用DNCB时对皮肤试验抗原产生了反应。皮肤试验结果与淋巴细胞亚群变化无关。
结论
DNCB治疗可改善HIV感染患者的DTH皮肤试验反应，表明对细胞免疫功能有积极作用。
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