Tsuchimochi S, Tamaki N, Kawamoto M, Tadamura E, Fujita T, Nohara R, Matsumori A, Sasayama S, Yonekura Y, Konishi J
Department of Nuclear Medicine, Kyoto University Faculty of Medicine.
Kaku Igaku. 1995 Jun;32(6):579-86.
Iodine-123 beta-methyl iodophenylpentadecanoic acid (BMIPP) has been used for evaluating myocardial fatty acid metabolism in vivo. The whole body BMIPP imaging was acquired in 26 patients (11 with HCM, 11 with CAD and 4 with DCM) to calculate % uptake in the myocardium and to correlate its uptake with biochemical data, including blood sugar (BS), nonesterified fatty acid (NEFA) and insulin in the blood. BMIPP was administered at rest with overnight fasting state, and the anterior and posterior whole body imaging was performed one hour later. The background corrected whole myocardial counts were calculated to obtain %BMIPP uptake. In addition, the heart to mediastinum count ratio (H/M ratio) was calculated from the mean counts in the heart and the upper mediastinum in the anterior view. The %BMIPP uptake was 3.70 +/- 1.22% and H/M ratio was 2.30 +/- 0.23. The patients with DCM showed higher %BMIPP uptake values (DCM = 5.58 +/- 0.67% vs. CAD = 3.09 +/- 0.97% and HCM = 3.63 +/- 0.86%, both p < 0.01), but similar values of H/M ratio with other patients (DCM = 2.43 +/- 0.20, CAD = 2.22 +/- 0.25 and HCM = 2.32 +/- 0.20). Although the biochemical data varied at the time of the tracer administration, they were not significantly correlated with the %BMIPP uptake or H/M ratio. However, there was a significant correlation between %BMIPP uptake and H/M ratio with the correlation coefficient of 0.80 (p < 0.001). We conclude that the myocardial uptake of BMIPP is not influenced by the plasma substrate level under the fasting state.
碘-123β-甲基碘代苯基十五烷酸（BMIPP）已被用于体内评估心肌脂肪酸代谢。对26例患者（11例肥厚型心肌病患者、11例冠心病患者和4例扩张型心肌病患者）进行全身BMIPP成像，以计算心肌摄取百分比，并将其摄取情况与生化数据相关联，这些生化数据包括血糖（BS）、血中非酯化脂肪酸（NEFA）和胰岛素。在空腹过夜状态下静息时给予BMIPP，1小时后进行前后位全身成像。计算背景校正后的全心肌计数以获得BMIPP摄取百分比。此外，从前位视图中的心和上纵隔的平均计数计算心与纵隔计数比（H/M比）。BMIPP摄取百分比为3.70±1.22%，H/M比为2.30±0.23。扩张型心肌病患者显示出更高的BMIPP摄取百分比值（扩张型心肌病=5.58±0.67%，冠心病=3.09±0.97%，肥厚型心肌病=3.63±0.86%，两者p<0.01），但与其他患者的H/M比相似（扩张型心肌病=2.43±0.20，冠心病=2.22±0.25，肥厚型心肌病=2.32±0.20）。尽管在给予示踪剂时生化数据有所不同，但它们与BMIPP摄取百分比或H/M比无显著相关性。然而，BMIPP摄取百分比与H/M比之间存在显著相关性，相关系数为0.80（p<0.001）。我们得出结论，在空腹状态下，血浆底物水平不影响BMIPP的心肌摄取。
