Basic fibroblast growth factor inhibited Ca2+ ionophore-induced apoptotic cell death of cultured cortical neurons from embryonic rats.
作者信息
Takei N, Ogaki H, Endo Y
机构信息
Department of Applied Biology, Kyoto Institute of Technology, Japan.
出版信息
Neurosci Lett. 1995 Jun 9;192(2):124-6. doi: 10.1016/0304-3940(95)11615-4.
PMID:7675319
Abstract
The effect of basic fibroblast growth factor (bFGF) on apoptotic cell death of cultured cortical neurons from embryonic rats induced by ionomycin, a potent Ca2+ ionophore, was investigated. bFGF inhibited Ca2+ ionophore-induced neurotoxicity in a dose-dependent manner. bFGF also reduced the degree of fragmentation of DNA of Ca2+ ionophore-treated neurons. These findings strongly suggest that bFGF inhibited ionomycin-induced neurotoxicity by preventing apoptosis.
摘要
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