肿瘤坏死因子-α在脂肪组织中的表达：在肥胖相关胰岛素抵抗中的直接作用。

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.

作者信息

Hotamisligil G S, Shargill N S, Spiegelman B M

机构信息

Dana-Farber Cancer Institute, Boston, MA.

出版信息

Science. 1993 Jan 1;259(5091):87-91. doi: 10.1126/science.7678183.

DOI:10.1126/science.7678183

PMID:7678183

Abstract

Tumor necrosis factor-alpha (TNF-alpha) has been shown to have certain catabolic effects on fat cells and whole animals. An induction of TNF-alpha messenger RNA expression was observed in adipose tissue from four different rodent models of obesity and diabetes. TNF-alpha protein was also elevated locally and systemically. Neutralization of TNF-alpha in obese fa/fa rats caused a significant increase in the peripheral uptake of glucose in response to insulin. These results indicate a role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity.

摘要

肿瘤坏死因子-α（TNF-α）已被证明对脂肪细胞和整个动物具有一定的分解代谢作用。在四种不同的肥胖和糖尿病啮齿动物模型的脂肪组织中观察到TNF-α信使核糖核酸表达的诱导。TNF-α蛋白在局部和全身也有所升高。在肥胖的fa/fa大鼠中中和TNF-α导致胰岛素刺激下外周葡萄糖摄取显著增加。这些结果表明TNF-α在肥胖中发挥作用，尤其在常伴随肥胖的胰岛素抵抗和糖尿病中起作用。