人类玻连蛋白受体α亚基基因（VNRA）在染色体2q31→q32上的区域定位。

Regional localization of the human vitronectin receptor alpha subunit gene (VNRA) to chromosome 2q31-->q32.

作者信息

Fernández-Ruiz E, Pardo-Manuel de Villena F, Rodríguez de Córdoba S, Sánchez-Madrid F

机构信息

Servicio de Immunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Spain.

出版信息

Cytogenet Cell Genet. 1993;62(1):26-8. doi: 10.1159/000133437.

DOI:10.1159/000133437

PMID:7678549

Abstract

The vitronectin receptor (av:beta 3; CD51/CD61), a member of the beta 3 integrin subfamily (cytoadhesins), functions as a receptor for a group of proteins that includes vitronectin, fibrinogen, thrombospondin, and von Willebrand factor. The human locus for the av gene (VNRA) was previously mapped to the long arm of chromosome 2 by DNA analysis of somatic cell hybrids. By using fluorescence in situ hybridization, coupled with GTG-banding, we have regionally mapped the human av gene to chromosome 2q31-->q32. An identical location was previously reported for the human gene coding for the integrin VLA-alpha 4 subunit (CD49D). These data, therefore, suggest the existence of a cluster of integrin genes at this chromosomal location.

摘要

玻连蛋白受体（αvβ3；CD51/CD61）是β3整合素亚家族（细胞粘附素）的成员，作为一组蛋白质的受体发挥作用，这些蛋白质包括玻连蛋白、纤维蛋白原、血小板反应蛋白和血管性血友病因子。通过对体细胞杂种的DNA分析，先前已将人类αv基因（VNRA）的基因座定位到2号染色体的长臂上。通过使用荧光原位杂交结合GTG显带技术，我们已将人类αv基因区域定位到2q31→q32。先前报道整合素VLA-α4亚基（CD49D）的人类基因也位于相同位置。因此，这些数据表明在该染色体位置存在一个整合素基因簇。