Gagliardi A, Collins D C
Research Service, Veterans Affairs Medical Center, Lexington, Kentucky.
Cancer Res. 1993 Feb 1;53(3):533-5.
In this study, we have determined the ability of the partial estrogen antagonists, clomiphene, tamoxifen, and nafoxidine, and the pure estrogen antagonists, ICI 164,384 and ICI 182,780, to inhibit angiogenesis in the chick egg chorioallantoic membrane. All of the partial estrogen antagonists and the pure estrogen antagonist, ICI 182,780, showed significant angiostatic activity in a dose-related manner. The addition of up to 5-fold of 17 beta-estradiol to the disks containing clomiphene, tamoxifen, or ICI 182,780 did not alter the angiostatic activity of these antiestrogens. These novel findings show that the antiestrogens are effective inhibitors of angiogenesis. The finding that angiostatic activity is not altered in the presence of excess estrogens suggests that this activity is exerted via mechanisms other than their inhibition of estrogen action. This angiostatic activity may contribute to the therapeutic effect of antiestrogens in estrogen receptor-negative tumors.
在本研究中，我们测定了部分雌激素拮抗剂氯米芬、他莫昔芬和那法瑞林，以及纯雌激素拮抗剂ICI 164,384和ICI 182,780抑制鸡胚绒毛尿囊膜血管生成的能力。所有部分雌激素拮抗剂和纯雌激素拮抗剂ICI 182,780均以剂量相关的方式表现出显著的血管生成抑制活性。向含有氯米芬、他莫昔芬或ICI 182,780的圆片中添加高达5倍的17β-雌二醇，并未改变这些抗雌激素药物的血管生成抑制活性。这些新发现表明，抗雌激素药物是血管生成的有效抑制剂。在存在过量雌激素的情况下血管生成抑制活性未改变这一发现表明，这种活性是通过其抑制雌激素作用以外的机制发挥的。这种血管生成抑制活性可能有助于抗雌激素药物对雌激素受体阴性肿瘤的治疗效果。
