脑一氧化氮合酶抑制剂NG-硝基-L-精氨酸对肥胖Zucker大鼠的厌食作用

Anorectic activity of NG-nitro-L-arginine, an inhibitor of brain nitric oxide synthase, in obese Zucker rats.

作者信息

Squadrito F, Calapai G, Cucinotta D, Altavilla D, Zingarelli B, Ioculano M, Urna G, Sardella A, Campo G M, Caputi A P

机构信息

Institute of Pharmacology, School of Medicine, University of Messina, Italy.

出版信息

Eur J Pharmacol. 1993 Jan 5;230(1):125-8. doi: 10.1016/0014-2999(93)90422-e.

DOI:10.1016/0014-2999(93)90422-e

PMID:7679075

Abstract

We investigated the effects of NG-nitro-L-arginine (L-NO Arg) administration (12.5, 25 and 50 mg/kg i.p.) on food consumption and body weight of male obese Zucker rats (fa/fa) and in their lean age-matched controls (FA/?; FA/FA), both groups aged 14 weeks. Acute or repeated administration of L-NO Arg reduced food intake and body weight in both obese and lean rats. However the lean rats showed tolerance to the L-NO Arg effects after 5 days of treatment. L-NO Arg anorexia was suppressed by pretreatment with metergoline. These results suggest that L-NO Arg may represent a new anorectic drug.

摘要

我们研究了腹腔注射NG-硝基-L-精氨酸（L-NO Arg，剂量分别为12.5、25和50mg/kg）对14周龄雄性肥胖 Zucker 大鼠（fa/fa）及其年龄匹配的瘦性对照大鼠（FA/?; FA/FA）食物摄入量和体重的影响。急性或重复给予L-NO Arg可降低肥胖和瘦性大鼠的食物摄入量和体重。然而，在治疗5天后，瘦性大鼠对L-NO Arg的作用产生了耐受性。麦角新碱预处理可抑制L-NO Arg引起的厌食。这些结果表明，L-NO Arg可能是一种新型的厌食药物。