Palmer A J, Lodge D
Department of Veterinary Basic Sciences, Royal Veterinary College, London, UK.
Eur J Pharmacol. 1993 Jan 15;244(2):193-4. doi: 10.1016/0922-4106(93)90027-7.
On rat cortical slices, cyclothiazide, 1-100 microM, (ED50 = 7.1 +/- 1.1 microM) enhanced the depolarizing action of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) but not that of N-methyl-D-aspartate (NMDA). Cyclothiazide 10 microM also reversed the action of a 2,3-benzodiazepine, GYKI 53655, which is a non-competitive AMPA receptor antagonist, but not that of the quinoxalinedione, NBQX, which is a competitive AMPA receptor antagonist.
在大鼠皮质切片上，1-100微摩尔的环噻嗪（半数有效浓度=7.1±1.1微摩尔）增强了α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）的去极化作用，但对N-甲基-D-天冬氨酸（NMDA）无此作用。10微摩尔的环噻嗪还能逆转2,3-苯并二氮杂䓬类药物GYKI 53655（一种非竞争性AMPA受体拮抗剂）的作用，但不能逆转喹喔啉二酮类药物NBQX（一种竞争性AMPA受体拮抗剂）的作用。
