Foster L S, Jajodia P, Fournier G, Shinohara K, Carroll P, Narayan P
Department of Urology, University of California, San Francisco School of Medicine.
J Urol. 1993 May;149(5):1024-8. doi: 10.1016/s0022-5347(17)36287-0.
The combination of prostate specific antigen (PSA) and transrectal ultrasonography was used to detect recurrent cancer in the prostatic fossa after radical prostatectomy. A total of 43 patients with persistently elevated PSA levels and negative bone scintigraphy following radical prostatectomy underwent digital rectal examination and transrectal ultrasonography. Ultrasound findings were considered suspicious if the scan showed any unusual hypoechoic tissue adjacent to the bladder neck, retro-trigone or peri-anastomotic site. Of 22 patients (51%) with biopsy proved cancer 21 (95%) had positive transrectal ultrasonography, while digital rectal examination was able to detect cancer in only 10 (45%). Among transrectal ultrasonography detected recurrences 15 (68%) were detected at the initial biopsy and 7 (32%) at repeat biopsies. Our study shows that the combination of PSA and transrectal ultrasonography provides a more effective method than digital rectal examination and PSA to detect biopsy proved cancer following radical prostatectomy.
前列腺特异性抗原（PSA）与经直肠超声检查相结合，用于检测前列腺癌根治术后前列腺窝的复发癌。共有43例前列腺癌根治术后PSA水平持续升高且骨扫描阴性的患者接受了直肠指检和经直肠超声检查。如果扫描显示膀胱颈、膀胱三角后或吻合口周围有任何异常低回声组织，则超声检查结果被视为可疑。在22例（51%）经活检证实为癌症的患者中，21例（95%）经直肠超声检查呈阳性，而直肠指检仅能检测出10例（45%）癌症。在经直肠超声检查发现的复发中，15例（68%）在初次活检时被发现，7例（32%）在重复活检时被发现。我们的研究表明，PSA与经直肠超声检查相结合，比直肠指检和PSA能提供更有效的方法来检测前列腺癌根治术后经活检证实的癌症。
