胸主动脉置换术后患者因重复应用抑肽酶导致严重过敏性休克。
Severe anaphylactic shock due to repeated application of aprotinin in patients following intrathoracic aortic replacement.
作者信息
Schulze K, Graeter T, Schaps D, Hausen B
机构信息
Department of Anesthesiology, Hannover Medical School.
出版信息
Eur J Cardiothorac Surg. 1993;7(9):495-6. doi: 10.1016/1010-7940(93)90280-o.
PMID:7692900
Abstract
Aprotinin is known to significantly reduce the incidence of perioperative bleeding complications in cardiac, thoracic and vascular surgery. Despite the wide use of this medication in other surgical fields, there are only a few reports of serious adverse side effects. In this paper we report on two patients with severe anaphylactic shock due to repeated administration of aprotinin, who both required cardiopulmonary resuscitation.
摘要
已知抑肽酶可显著降低心脏、胸科和血管手术围手术期出血并发症的发生率。尽管这种药物在其他外科领域广泛使用，但关于严重不良副作用的报道却很少。在本文中，我们报告了两名因重复使用抑肽酶而发生严重过敏性休克的患者，两人均需进行心肺复苏。
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