Tempel D L, Leibowitz S F
Rockefeller University, New York, New York 10021.
Am J Physiol. 1993 Nov;265(5 Pt 1):E794-800. doi: 10.1152/ajpendo.1993.265.5.E794.
Norepinephrine (NE) and neuropeptide Y (NPY) potentiate carbohydrate ingestion after injection into the paraventricular nucleus (PVN), whereas injection of galanin (Gal) potentiates fat intake. The present study examines the relation between these neurochemically induced feeding behaviors and the adrenal steroids acting locally within the PVN. Results demonstrate that PVN NE- and NPY-induced carbohydrate intake is abolished by adrenalectomy surgery (ADX) and by local PVN implants of the type II receptor antagonist RU-486. Carbohydrate intake in response to PVN NE or NPY injection is unaffected by the type I antagonist RU-28318. In contrast, the stimulatory effect of PVN Gal injection on fat intake is unchanged by surgical ADX or by PVN administration of RU-486 or RU-28318, suggesting that the stimulatory action of Gal on fat ingestion occurs independently of corticosterone (Cort) and of PVN type I or type II steroid receptors. It is concluded that endogenous Cort has a permissive effect on the carbohydrate feeding responses elicited by NE and NPY in the PVN and that this interaction is mediated by type II glucocorticoid receptors within this nucleus.
去甲肾上腺素（NE）和神经肽Y（NPY）注入室旁核（PVN）后会增强碳水化合物的摄取，而注入甘丙肽（Gal）则会增强脂肪的摄取。本研究探讨了这些神经化学诱导的摄食行为与在PVN局部起作用的肾上腺类固醇之间的关系。结果表明，肾上腺切除术（ADX）以及PVN局部植入II型受体拮抗剂RU - 486可消除PVN中NE和NPY诱导的碳水化合物摄取。对PVN注射NE或NPY所产生的碳水化合物摄取不受I型拮抗剂RU - 28318的影响。相反，PVN注射Gal对脂肪摄取的刺激作用不会因手术ADX或PVN给予RU - 486或RU - 28318而改变，这表明Gal对脂肪摄取的刺激作用独立于皮质酮（Cort）以及PVN的I型或II型类固醇受体而发生。得出的结论是，内源性Cort对PVN中NE和NPY引发的碳水化合物摄食反应具有允许作用，并且这种相互作用是由该核内的II型糖皮质激素受体介导的。
