[764-3对博来霉素A6诱导的肺泡巨噬细胞形态学变化的影响]
[The effect of 764-3 on alveolar macrophage morphologic changes induced by BLM-A6].
作者信息
Chi S, Yan Y
机构信息
Institute of Basic Medical Sciences, Beijing.
出版信息
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1993 Apr;15(2):94-7.
The morphologic changes of alveolar macrophages (AM) were observed by electron microscopy, computer controlled image analysis and stereoscopy. The results showed that 764-3 had no effect on normal AM morphology and structure, but inhibited the BLM-A6 induced increase of volume, specific surface, and lysosome volume density of AM. At the same time, the spreading ability of AM on the slide was markedly reduced by 764-3, indicating that 764-3 can partially prevent the AM activation caused by BLM-A6 in vitro.
通过电子显微镜、计算机控制图像分析和体视学观察肺泡巨噬细胞（AM）的形态学变化。结果显示，764-3对正常AM的形态和结构无影响，但抑制博来霉素A6（BLM-A6）诱导的AM体积、比表面积和溶酶体体积密度增加。同时，764-3使AM在玻片上的铺展能力显著降低，表明764-3在体外可部分阻止BLM-A6引起的AM活化。
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