肽核酸的正离子快原子轰击串联质谱分析
Positive-ion fast-atom bombardment tandem mass spectrometry of peptide nucleic acids.
作者信息
Takao T, Fukuda H, Coull J, Shimonishi Y
机构信息
Institute for Protein Research, Osaka University, Japan.
出版信息
Rapid Commun Mass Spectrom. 1994 Dec;8(12):925-8. doi: 10.1002/rcm.1290081203.
PMID:7696700
Abstract
The base sequence of synthetic peptide nucleic acids (PNAs), novel antisense agents, was analyzed by positive-ion fast-atom bombardment tandem mass spectrometry (FAB-MS/MS). Upon high-energy collisional activation decomposition, PNA oligomers provided apparent MS/MS product ions resulting from specific cleavage along the PNA backbone.
摘要
通过正离子快原子轰击串联质谱法（FAB-MS/MS）分析了新型反义剂合成肽核酸（PNA）的碱基序列。在高能碰撞激活分解过程中，PNA寡聚物产生了沿PNA主链特异性裂解产生的明显的MS/MS产物离子。
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