Brown N L, Sattler C A, Paddock S W, Carroll S B
Howard Hughes Medical Institute, University of Wisconsin Madison 53706.
Cell. 1995 Mar 24;80(6):879-87. doi: 10.1016/0092-8674(95)90291-0.
The initial steps of pattern formation in the developing Drosophila eye involve the coordination of cell cycles, changes in cell shape, and the specification of the R8 photoreceptor cell. These events begin several cell rows ahead of the morphogenetic furrow and are positively regulated by secreted signaling proteins and the proneural HLH transcription factor atonal (ato). Two HLH regulatory proteins that function to suppress neuronal development in other tissues, extra macrochaetae (emc) and hairy (h), are expressed ahead of the morphogenetic furrow. While neither h nor emc is required for photoreceptor cell determination, in emc-h-clones the morphogenetic furrow and differentiated eye field advance up to eight ommatidial rows ahead of adjacent wild-type tissue. This indicates that morphogenetic furrow progression and neuronal differentiation are negatively regulated by a combination of anteriorly expressed HLH regulatory proteins.
果蝇发育中的眼睛图案形成的初始步骤涉及细胞周期的协调、细胞形状的变化以及R8光感受器细胞的特化。这些事件在形态发生沟前方的几排细胞处开始，并受到分泌的信号蛋白和神经前体HLH转录因子无调性（ato）的正向调节。两种在其他组织中起抑制神经元发育作用的HLH调节蛋白，超大刚毛（emc）和毛状（h），在形态发生沟之前表达。虽然h和emc都不是光感受器细胞决定所必需的，但在emc-h克隆中，形态发生沟和分化的眼区比相邻的野生型组织提前多达八排小眼前进。这表明形态发生沟的进展和神经元分化受到前部表达的HLH调节蛋白组合的负向调节。
