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80岁以上患者的心肌梗死。关于157例病例

[Myocardial infarction after 80 years of age. Apropos of 157 cases].

作者信息

Malaterre H R, Daver L, Deharo J C, Bory M, Djiane P

机构信息

Centre médico-chirurgical des hôpitaux Sud Cantini II, service de cardiologie du Pr Djiane, hôpital Sainte-Marguerite, Marseille.

出版信息

Arch Mal Coeur Vaiss. 1994 Jul;87(7):875-81.

PMID:7702430
Abstract

The authors evaluated the features of myocardial infarctions in a population of 157 subjects aged 80 years or more out of a total of 1,610 patients admitted for myocardial infarction. It was a common condition in this age group (9.8% of the population) with a female predominance (61.8%), the main risk factor begin hypertension. A previous history of angina or infarctions, silent ischaemia, atypical electrocardiographic forms and anterior infarction were significantly more common. The outcome was characterised by a higher prevalence of haemodynamic complications with cardiac failure in 60% of cases and cardiogenic shock in 10% of cases. Atrial fibrillation was also more common though severe ventricular arrythmias were more infrequent. From the therapeutic point of view, 95.7% of octogenarians were given intravenous heparin but thrombolysis was undertaken in only one case. Coronary angiography, angioplasty and cardiac surgery were exceptional. Hospital mortality was 26.7%, seven times higher than that observed in patients under 65 years of age and nearly twice that of patients 65 to 79 years of age. After hospital admission, 45% of octogenarians were prescribed a calcium inhibitor, 37.2% a platelet anti-aggregant agent, 17.2% long-term oral anticoagulants and 1.9% a betablocker. These results show that myocardial infarction after 80 years of age is common, serious, but treated conventionally.

摘要

作者在1610例因心肌梗死入院的患者中,评估了157例80岁及以上患者的心肌梗死特征。这在该年龄组中是一种常见病症(占该人群的9.8%),女性占主导(61.8%),主要危险因素是高血压。既往有心绞痛或心肌梗死病史、无症状性缺血、非典型心电图形式和前壁梗死更为常见。结果显示血流动力学并发症的发生率较高,60%的病例出现心力衰竭,10%的病例出现心源性休克。房颤也更常见,尽管严重室性心律失常较少见。从治疗角度看,95.7%的八旬老人接受了静脉肝素治疗,但仅1例进行了溶栓治疗。冠状动脉造影、血管成形术和心脏手术很少进行。医院死亡率为26.7%,比65岁以下患者高出7倍,几乎是65至79岁患者的两倍。入院后,45%的八旬老人被开了钙抑制剂,37.2%被开了血小板抗聚集剂,17.2%被开了长期口服抗凝剂,1.9%被开了β受体阻滞剂。这些结果表明,80岁以后的心肌梗死很常见、病情严重,但采用常规治疗。

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