白色念珠菌营养缺陷型突变体在大鼠口腔念珠菌病模型中的无毒力

Avirulence of Candida albicans auxotrophic mutants in a rat model of oropharyngeal candidiasis.

作者信息

Cole M F, Bowen W H, Zhao X J, Cihlar R L

机构信息

Department of Microbiology and Immunology, Georgetown University, Washington, DC 20007.

出版信息

FEMS Microbiol Lett. 1995 Feb 15;126(2):177-80. doi: 10.1111/j.1574-6968.1995.tb07413.x.

DOI:10.1111/j.1574-6968.1995.tb07413.x

PMID:7705609

Abstract

The virulence of Candida albicans strain SC5413 and two isogenic derivatives have been investigated in a rat model of oropharyngeal candidiasis. The results demonstrate that both mutant strains are avirulent in this animal model while the parental strain readily initiates infection. Avirulence is not related to altered growth characteristics or the inability of the strains to undergo yeast-to-hyphal morphogenesis. The potential importance of nutritional sufficiency as a virulence factor as well as the possibility of utilizing such strains in the development of an in vitro expression technology system for Candida albicans is discussed.

摘要

在大鼠口腔念珠菌病模型中研究了白色念珠菌菌株SC5413及其两个同基因衍生物的毒力。结果表明，在该动物模型中，两种突变菌株均无毒力，而亲代菌株很容易引发感染。无毒力与生长特性改变或菌株无法进行酵母到菌丝的形态发生无关。讨论了营养充足作为毒力因子的潜在重要性，以及利用这些菌株开发白色念珠菌体外表达技术系统的可能性。