每日一次庆大霉素在血液系统恶性肿瘤中性粒细胞减少成人患者中的药代动力学。

The pharmacokinetics of once daily gentamicin in neutropenic adults with haematological malignancy.

作者信息

MacGowan A P, Bedford K A, Blundell E, Brown N M, Habib F, Hows J, Kirkpatrick B, Korner R J, Slade R R, White L O

机构信息

Department of Medical Microbiology, Southmead Health Services NHS Trust, Westbury-on-Trym, Bristol, UK.

出版信息

J Antimicrob Chemother. 1994 Nov;34(5):809-12. doi: 10.1093/jac/34.5.809.

DOI:10.1093/jac/34.5.809

PMID:7706178

Abstract

Seven febrile neutropenic adults with normal renal function were treated with intravenous gentamicin 4.5 mg/kg once a day in combination with azlocillin. Gentamicin serum concentrations 1, 2, 4, 8, and 24 h after a 30 min infusion were 10.9 +/- 0.6, 7.1 +/- 0.4, 4.2 +/- 0.2, 1.8 +/- 0.1 and 0.16 +/- 0.003 mg/L respectively. The pharmacokinetics were best described by a triphasic plot including a distribution phase (about 1/2 h) and two elimination phases, an early and late.

摘要

七名肾功能正常的发热性中性粒细胞减少症成年患者接受了静脉注射庆大霉素治疗，剂量为4.5mg/kg，每日一次，并联合使用阿洛西林。在30分钟输注后1、2、4、8和24小时的庆大霉素血清浓度分别为10.9±0.6、7.1±0.4、4.2±0.2、1.8±0.1和0.16±0.003mg/L。药代动力学最好用三相图来描述，包括一个分布相（约1/2小时）和两个消除相，即早期和晚期。