Deacon H E, Freese J A, Sharp B L
National Malaria Research Programme of the South African Medical Research Council (Natal), Durban.
S Afr Med J. 1994 Jul;84(7):394-5.
In March 1993, a study was undertaken in the Komatipoort/Malelane area to monitor the in vitro sensitivity of Plasmodium falciparum to antimalarial drugs currently in use in South Africa. Of the 12 isolates collected, 7 were successfully tested for sensitivity to chloroquine and quinine, 6 for mefloquine susceptibility, and 5 for sensitivity to Fansidar. Four of the isolates were resistant to chloroquine at RIII level, 1 at RII level, and 2 were sensitive. All isolates were found to be sensitive to both quinine and mefloquine. Results suggested possible resistance to Fansidar. These findings have implications for tourists travelling to this area.
1993年3月，在科马蒂普特/马勒拉内地区开展了一项研究，以监测恶性疟原虫对南非目前使用的抗疟药物的体外敏感性。在收集的12株分离株中，7株成功测试了对氯喹和奎宁的敏感性，6株测试了对甲氟喹的敏感性，5株测试了对 Fansidar 的敏感性。其中4株分离株对氯喹呈RIII级耐药，1株呈RII级耐药，2株敏感。所有分离株对奎宁和甲氟喹均敏感。结果提示可能对 Fansidar 耐药。这些发现对前往该地区的游客有影响。
