Zhang K M, Zhao Z Q
Shanghai Brain Research Institute, Chinese Academy of Sciences.
Zhongguo Yao Li Xue Bao. 1994 Nov;15(6):491-4.
The effect of alpha 2-adrenoceptor antagonist yohimbine (Yoh) on locus coeruleus (LC)-induced spinal antinociception was investigated in 18 anesthetized Wistar rats. Stimulation of LC markedly inhibited both nociceptive reflex of the posterior biceps semitendinosus (PBST) muscle and C responses of 16 wide-dynamic range (WDR) neurons of the dorsal horn. Application of Yoh (0.2%, 5-10 microliters) to the surface of spinal cord at L3-4 attenuated the LC-induced inhibition of nociceptive reflex without affecting that of C responses of 10 WDR neurons that were tested in 6 rats. The results suggested that LC may exert its inhibitory action on the nociceptive reflex via alpha 2 adrenoceptors somewhere other than the WDR neurons in the spinal dorsal horn.
在18只麻醉的Wistar大鼠中研究了α2-肾上腺素能受体拮抗剂育亨宾（Yoh）对蓝斑（LC）诱导的脊髓镇痛作用的影响。刺激LC可显著抑制半腱肌肱二头肌（PBST）的伤害性反射以及背角16个广动力范围（WDR）神经元的C反应。将Yoh（0.2%，5 - 10微升）应用于L3 - 4脊髓表面，可减弱LC诱导的伤害性反射抑制作用，但不影响在6只大鼠中测试的10个WDR神经元的C反应抑制作用。结果表明，LC可能通过脊髓背角WDR神经元以外的其他部位的α2肾上腺素能受体对伤害性反射发挥抑制作用。
