用亲脂性自由基引发剂制备的含半乳糖两亲分子。

Galactose-containing amphiphiles prepared with a lipophilic radical initiator.

作者信息

Kitano H, Sohda K, Kosaka A

机构信息

Department of Chemical and Biochemical Engineering, Toyama University, Japan.

出版信息

Bioconjug Chem. 1995 Jan-Feb;6(1):131-4. doi: 10.1021/bc00031a016.

DOI:10.1021/bc00031a016

PMID:7711099

Abstract

Novel amphiphiles which contain galactose residues (degree of polymerization (DP) = 6.2, 10, and 15) were prepared by telomerization of 2-[(methacryloyloxy)ethyl]-beta-D-galactopyranoside using a lipophilic radical initiator. The galactose-carrying amphiphile incorporated in a liposome was recognized by a lectin from Ricinus communis (RCA120), which was proven by the increase in turbidity of the liposome suspension after mixing with the lectin. The recognition was largely affected by the degree of polymerization and the surface density of the amphiphile. The amphiphile would be useful as a component of the drug delivery system to hepatocytes.

摘要

通过使用亲脂性自由基引发剂对2-[(甲基丙烯酰氧基)乙基]-β-D-吡喃半乳糖苷进行端粒化反应，制备了含有半乳糖残基（聚合度（DP）= 6.2、10和15）的新型两亲物。包裹在脂质体中的携带半乳糖的两亲物被蓖麻凝集素（RCA120）识别，这通过与凝集素混合后脂质体悬浮液的浊度增加得到证实。这种识别在很大程度上受到两亲物的聚合度和表面密度的影响。该两亲物可作为肝细胞药物递送系统的一个组成部分。